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Image is a direct output of the VSBONE BSI clinical computer-aided diagnosis (CAD) software (Nihon Medi-Physics Co., Ltd., Tokyo, Japan), displaying actual bone scintigraphy images of a 61-year-old patient with hepatocellular carcinoma. BSI: Bone Scan Index; HSn: hotspot number.

Journal: Cureus

Article Title: Evaluating the Impact of Sex-Specific Artificial Intelligence on Bone Metastasis Detection: VSBONE Bone Scan Index (BSI) Version 2.1 Versus Version 3.0

doi: 10.7759/cureus.106562

Figure Lengend Snippet: Image is a direct output of the VSBONE BSI clinical computer-aided diagnosis (CAD) software (Nihon Medi-Physics Co., Ltd., Tokyo, Japan), displaying actual bone scintigraphy images of a 61-year-old patient with hepatocellular carcinoma. BSI: Bone Scan Index; HSn: hotspot number.

Article Snippet: Objective(s): The present study compared the diagnostic accuracy of two different versions of an AI-assisted computer-aided diagnosis (CAD) software (VSBONE versions 2.1 and 3.0, Nihon Medi-Physics, Tokyo, Japan) for detecting bone metastases using bone scintigraphy images, with a focus on evaluating the impact of the new sex-specific analysis feature in version 3.0 on the overall performance and diagnostic accuracy in clinical decision-making.

Techniques: Biomarker Discovery, Software

Effect of stefin B and cystatin C deficiency on proliferation and cell death. ( A ) Cell proliferation in primary tumors was determined through immunodetection of Ki67 in PyMT;WT and PyMT;DKO mice at 14 weeks of age. Representative images and quantification of Ki67-positive cells as a percentage of total cells in PyMT;WT (n = 11) and PyMT;DKO (n = 10) tumors. Ki67 index was calculated from 10 high-power fields per tumor using computer-assisted data analysis in ImageJ. Differences were analyzed using Student’s t -test. ( B ) Cell death in primary tumors from PyMT;WT and PyMT;DKO mice at 14 weeks of age was determined through TUNEL assays. Representative images and quantification of TUNEL-positive cells as a percentage of total cells in PyMT;WT (n = 9) and PyMT;DKO (n = 8) tumors. The TUNEL+ index was calculated from 10 high-power fields per tumor using computer-assisted data analysis in ImageJ. Differences were analyzed using Student’s t -test.

Journal: Cells

Article Title: Stefin B and Cystatin C Deficiency Suppresses Tumor Growth and Alters Tumor Microenvironment in a Breast Cancer Model

doi: 10.3390/cells15040360

Figure Lengend Snippet: Effect of stefin B and cystatin C deficiency on proliferation and cell death. ( A ) Cell proliferation in primary tumors was determined through immunodetection of Ki67 in PyMT;WT and PyMT;DKO mice at 14 weeks of age. Representative images and quantification of Ki67-positive cells as a percentage of total cells in PyMT;WT (n = 11) and PyMT;DKO (n = 10) tumors. Ki67 index was calculated from 10 high-power fields per tumor using computer-assisted data analysis in ImageJ. Differences were analyzed using Student’s t -test. ( B ) Cell death in primary tumors from PyMT;WT and PyMT;DKO mice at 14 weeks of age was determined through TUNEL assays. Representative images and quantification of TUNEL-positive cells as a percentage of total cells in PyMT;WT (n = 9) and PyMT;DKO (n = 8) tumors. The TUNEL+ index was calculated from 10 high-power fields per tumor using computer-assisted data analysis in ImageJ. Differences were analyzed using Student’s t -test.

Article Snippet: The average size of metastases was quantified using computer-assisted analysis with CellSens Imaging software (Version 1.17; Olympus, Tokyo, Japan).

Techniques: Immunodetection, TUNEL Assay